Publications

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SARRP Publications

    1. Tuli R, Surmak A, Reyes J, Hacker-Prietz A, Armour M, Leubner A, Blackford A, Tryggestad E, Jaffee EM, Wong J, DeWeese TL, Herman JL (2012). Development of a Novel Preclinical Cancer Research Model: Bioluminescence Image-Guided Focal Irradiation and Tumor Monitoring of Orthotopic Xenografts. Translational Oncology. (Vol 5, No 2). Johns Hopkins, Baltimore USA

    2. Lee DA, Bedont JL, Pak T, Wang H, Song J, Miranda-Angulo A, Takiar V, Charubhumi V, Balordi F, Takebayashi H, Aja S, Ford E, Fishell G, Blackshaw S (2012). Tancytes of the hypothalamic median eminence form a diet-responsive neurogenic niche. Nature Neuroscience. Nature.com. USA

    3. Korideck H, Ngwa W, Makrigiogos GM, Berbeco RI (2011).The quantification of gold nanoparticles as contrast agents for small animal volumetric studies. ASTRO 2011 Conference Poster. Harvard Medical School; Boston, USA

    4. Ngwa W, Korideck H, Chin LM, Makrigiorgos GM, Berbeco RI (2011). MOSFET Assessment of radiation dose delivered to mice using the small animal radiation platform (SARRP). Radiation Research. Harvard Medical School; Boston, USA

    5. Cao X, Wu X, Frassica D, Yu B, Pang L, Xian L, Wan M, Lei W, Armour M, Tryggestad E, Wong J, Wen, CY, Lu WW, Frassica FJ (2011). Irradiation induces bone injury by damaging bone marrow microenvironment for stem cells. Proceedings. http://www.pnas.org

    6. Ford EC, Achanta P, Purger D, Armour M, Reyes J, Fong J, Kleinberg L, Redmond K, Wong J, Jang MH, Jun H, Song HJ, Quinones-Hinojosa A (2011). Localized CT-guided irradiation inhibits neurogenesis in specific regions of the adult mouse brain. Radiation Research. Department of Radiation Oncology and Molecular Radiation Sciences: The Johns Hopkins University School of Medicine; Baltimore, USA

    7. Zhou J, Tryggestad E, Wen Z, Lal B, Zhou T, Grossman R, Wang S, Yan K, Fu D, Ford E, Tyler B, Blakely J, Laterra J, Van Zijl PCM (2010). Differentiation between glioma and radiation necrosis using molecular magnetic resonance imaging of endogenous proteins and peptides. Nature Medicine 17; Nature.com USA

    8. Jacques R, Taylor R, Wong J, McNutt T (2010). Towards real-time radiation therapy: GPU accelerated superposition/convolution. Comput Methods Programs Biomed 98 (3). The Johns Hopkins University School of Medicine; Baltimore, USA

    9. Matinfar M, Iyer S, Ford E, Wong J, Kazanzides P (2010). Treatment planning and delivery of shell dose distribution for precision irradiation. Proceedings (Vol 7625); Poster Session: Radiation Therapy; http://www.spiedigitallibrary.org

    10. Armour M, Ford E, Iordachita I, Wong J (2010). CT guidance is needed to achieve reproducible positioning of the mouse head for repeat precision cranial irradiation. Radiation Research. Department of Radiation Oncology and Molecular Radiation Sciences: The Johns Hopkins University School of Medicine; Baltimore, USA

    11. E Tryggestad et al (2009). A comprehensive system for dosimetric commissioning and Monte Carlo validation for the small animal radiation research platform. Physics in Medicine and Biology (Vol 54, No 17).

    12. Mohammad Matinfar et al (2009). Image-guided small animal radiation research platform: calibration of treatment beam alignment. Physics in Medicine and Biology (Vol 54, No 4).

    13. Duan W, Peng Q, Masuda N, Ford E, Tryggestad E, Ladenheim B, Zhao M, Cadet JL, Wong J, Ross CA (2008). Sertraline slows disease progression and increases neurogenesis in N171-82Q mouse model of Huntington's disease. Neurobiology of Disease 30 (p. 312-322) USA

    14. Matinfar M, Iordachita I, Ford E, Wong J, Kazanzides P (2008). Precision radiotherapy for small animal research. Medical Image Computing and Computer-Assisted Intervention: MICCAI (conference). Department of Computer Sciences: The Johns Hopkins University; Baltimore, USA.

    15. Wong J, Armour E, Kazanzides P, Iordachita I, Tryggestad E, Deng H, Matinfar M, Kennedy C, Liu Z, Chan T, Gray O, Verhaegen F, McNutt T, Ford E, DeWeese TL (2008). High-resolution, small animal radiation research platform with x-ray tomographic guidance capabilities. International Journal of Radiation Oncology, Biology Physics. Department of Radiation Oncology and Molecular Radiation Sciences: The Johns Hopkins University School of Medicine; Baltimore, USA

    16. Chan S, Armstrong T, Nava-Pavada P, Swartz M, Sugar E, Zhang Y, Tryggestad E, Emens L, Jaffee E, Herman JM (2008). Evaluation of the immunomodulatory effects of stereotactic radiation therapy (SRT) and GM-CSF whole cell vaccine (GVAX) in a pancreatic tumor model. 2008 Gastrointestinal Cancers Symposium (meeting poster). American Society of Clinical Oncology Abstracts: http://www.asco.org

    17. Matinfar M, Gray O, Iordachita I, Kennedy C, Ford E, Wong J, Raylor RH, Kazanzides P (2007). Small animal radiation research platform: imaging, mechanics, control and calibration. Medical Image Computing and Computer-Assisted Intervention: MICCAI (conference). Department of Computer Sciences: The Johns Hopkins University; Baltimore, USA

    18. Hua Deng et al (2007). The small-animal radiation research platform (SARRP): dosimetry of a focused lens system. Physics in Medicine and Biology (Vol 52, No 10).

    Click here for Irradiation Cabinet Publications

Xstrahl

Xstrahl Research Platform Links

  1. Xstrahl RS225 at Nottingham University
  2. UCL London

SARRP Research Platform Advantages

  • Provides state-of-the-art 3D volumetric image guidance for localization and targeting of the dose
  • Conformal dose minimizes exposure to non-targeted tissues and organs
  • Non-invasive procedure
  • Easy to use, reliable, and reproducible
  • Customizable to meet new and innovative applications
  • High resolution, low imaging dose, on board CT imaging and 3D reconstruction
  • Image fusion options for easy target localization and avoidance of organs at risk
  • High precision beam geometry to achieve conformal dose distributions
  • Open platform to enable the addition of other imaging modalities for future research
SAARP Research Platform

SARRP System Features

  • Isocenter accuracy to 0.25 mm
  • On board cone beam CT and image reconstruction
  • Minimum field size of 0.5 mm diameter
  • Gantry and robotic specimen stage enable non-coplanar field arrangements

In addition, Xstrahl offers a range of stand alone X-Ray cabinets for more general lab-based irradiation techniques.

Applications

The SARRP research platform enables researchers to replicate the radiotherapy process of imaging, target localization and radiotherapy treatment delivery techniques employed when treating patients in clinical oncology departments. In order to improve the efficiency of radiation therapy and minimize the short and long term side effects of cancer treatment it is vital to study radiation biology using in vivo models.

  • Radiobiology
  • Pre clinical studies
  • DNA damage response
  • Tumour biology and the micro-environment
  • Bystander effects
  • Radiosensitizers
  • Cardiovascular toxicity
  • Oncology research
    • Preclinical validation of radiotherapy – assessing the risks of radiation exposure are balanced against the efficacy of the treatment in controlling and eliminating tumours
    • Characterize tumours that may not respond to ionizing radiation
    • DNA damage response
    • Can couple spatially targeted radiotherapy with molecularly targeted therapies to optimize treatments for solid tumours
    • Mechanism of tumour control
  • Normal tissue injury by radiotherapy
  • Immunology disease
  • Cardiovascular diseases
  • Radiobiological effectiveness

Links & Downloads


Brochure
Xstrahl SARRP Brochure »
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Brochure
Xstrahl SARRP Brochure »
PDF 451 kb

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