Publications
Irradiation Cabinet Publications
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Tischner D, Theiss J, Karabinskaya A, van den Brandt J, Reichardt SD, Karow U, Herold MJ, Lühder F, Utermöhlen O, Reichardt HM (2011). Acid sphingomyelinase is required for protection of effector memory T cells against glucocorticoid-induced cell death. The Journal of Immunology, Vol. 187 (9). Germany
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Toulany M, Schickfluß T, Eicheler W, Kehlbach R, Schittek B, Rodemann P (2011). Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiation. Breast Cancer Research, Vol 13 (2) . Germany
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Sohn D, Budach W, Jänicke R (2011). Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21. Cell Death and Differentiation, Vol 18 (10). Germany
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Kasten-Pisula U, Saker J, Eicheler W, Krause M, Yaromina A, Meyer-Staeckling S, Scherkl B, Kriegs M, Brandt B, Grénman R, Petersen C, Baumann M, Dikomey E (2011). Cellular and tumor radiosensitivity is correlated to epidermal growth factor receptor protein expression level in tumors without EGFR amplification. International Journal of Radiation Oncology, Biology, Physics. Vol 80 (4). Germany
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Lynam-Lennon N, Reynolds JV, Pidgeon GP, Lysaght J, Marignol L, Maher SG (2010). Alterations in DNA repair efficiency are involved in the radioresistance of esophageal adenocarcinoma. Radiation Research, Vol 174 (6). Ireland
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Chen L, Iraci N, Gherardi S, Gamble LD, Wood KM, Perini G, Lunec J, Tweddle DA (2010). p53 is a direct transcriptional target of MYCN in neuroblastoma. Cancer Research, Vol 70 (4). United Kingdom.
Drew Y, Mulligan EA, Vong WT, Thomas HD, Kahn S, Kyle S, Mukhopadhyay A, Los G, Hostomsky Z, Plummer ER, Edmondson RJ, Curtin NJ (2010). Therapeutic potential of poly (ADP-ribose) polymerase Inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2. Journal of the National Cancer Institute, Vol 103 (4). United Kingdom
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Martin L, Marples B, Coffey M, Lawler M, Hollywood D, Marignol L (2009). Recognition of 06MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity. Radiation Research, Vol 172 (4). Ireland
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Welke K, Schneider JM (2009). Inbreeding avoidance through cryptic female choice in the cannibalistic orb-web spider Argiope lobata. Behavioral Ecology, Vol 20 (5). Germany
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Schneider JM, Lesmono K (2009). Courtship raises male fertilization success through post-mating sexual selection in a spider. Proceedings in Biological Sciences. Germany
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Nessler SH, Uhl G, Schneider JM (2009). Sexual cannibalism facilitates genital damage in Argiope lobata (Araneae: Araneidae). Behavioral Ecoloogy and Sociobiology, Vol 63 (3). Germany
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Marignol L, Foley R, Southgate TD, Coffey M, Hollywood D, Lawler M (2009). Hypoxia response element-driven cytosine deaminase/5-fluorocytosine gene therapy system: a highly effective approach to overcome the dynamics of tumour hypoxia and enhance the radiosensitivity of prostate cancer cells in vitro. The Journal of Gene Medicine, Vol 11 (2). Ireland.
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Wanner G, Mayer C, Kehlbach R, Rodemann HP, Dittmann K (2008). Activation of protein kinase Cepsilon stimulates DNA-repair via epidermal growth factor receptor nuclear accumulation. Radiotherapy & Oncology, Vol 86 (3). Germany
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Dittman K, Mayer C, Kehlbach R, Rodemann HP (2008). Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK. Molecular Cancer, Vol 7 (69). Germany
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Prevo R, Deutsch E, Sampson O, Diplexcito J, Cenjel K, Harper J, O'Neill P, McKenna WG, Patel S, Bernhard EJ (2008). Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine Inhibitor PI-103 enhances tumor radiosensitivity. Cancer Research, Vol 68. United Kingdom
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Dittmann K, Mayer C, Wanner G, Kehlbach R, Rodemann HP (2007). The radioprotector O-phospho-tyrosine stimulates DNA-repair via epidermal growth factor receptor-and-DNA-dependent kinase phosphorylation. Radiotherapy & Oncology, Vol 84 (3). Germany
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Toulany M, Baumann M, Rodemann HP (2007). Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity. Molecular Cancer Research, Vol 5 (8). Germany
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Bell E, Premkumar R, Carr J, Lu X, Lovat PE, Kees UR, Lunec J, Tweddle DA (2006). The role of MYCN in the failure of MYCN amplified neuroblastoma cell lines to G1 arrest after DNA damage. Cell Cycle, Vol 5 (22). United Kingdom
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Dittmann K, Mayer C, Rodemann HP (2005). Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity. Radiotherapy & Oncology, Vol 76 (2). Germany.
Click for SARRP Publications
Applications:
Research applications include:
- Oncology
- Radiobiology tumour micro-environment
- DNA repair
- Bystander effects
- Radiosensitivity of normal tissue
- Preclinical studies
- Radiosensitizsers
Other applications include:
- In vivo irradiation
Control System
Operator time is kept to a minimum which enables research application and calibration programs to be easily formulated and programmed into the control systems. Both research and calibration equipment incorporates a touch screen controller.
Links & Downloads
Datasheets
Xstrahl RS225 Data Sheet »
PDF 63 kb
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