Publications

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Irradiation Cabinet Publications

    1. Tischner D, Theiss J, Karabinskaya A, van den Brandt J, Reichardt SD, Karow U, Herold MJ, Lühder F, Utermöhlen O, Reichardt HM (2011). Acid sphingomyelinase is required for protection of effector memory T cells against glucocorticoid-induced cell death. The Journal of Immunology, Vol. 187 (9). Germany

    2. Toulany M, Schickfluß T, Eicheler W, Kehlbach R, Schittek B, Rodemann P (2011). Impact of oncogenic K-RAS on YB-1 phosphorylation induced by ionizing radiation. Breast Cancer Research, Vol 13 (2) . Germany

    3. Sohn D, Budach W, Jänicke R (2011). Caspase-2 is required for DNA damage-induced expression of the CDK inhibitor p21. Cell Death and Differentiation, Vol 18 (10). Germany

    4. Kasten-Pisula U, Saker J, Eicheler W, Krause M, Yaromina A, Meyer-Staeckling S, Scherkl B, Kriegs M, Brandt B, Grénman R, Petersen C, Baumann M, Dikomey E (2011). Cellular and tumor radiosensitivity is correlated to epidermal growth factor receptor protein expression level in tumors without EGFR amplification. International Journal of Radiation Oncology, Biology, Physics. Vol 80 (4). Germany

    5. Lynam-Lennon N, Reynolds JV, Pidgeon GP, Lysaght J, Marignol L, Maher SG (2010). Alterations in DNA repair efficiency are involved in the radioresistance of esophageal adenocarcinoma. Radiation Research, Vol 174 (6). Ireland

    6. Chen L, Iraci N, Gherardi S, Gamble LD, Wood KM, Perini G, Lunec J, Tweddle DA (2010). p53 is a direct transcriptional target of MYCN in neuroblastoma. Cancer Research, Vol 70 (4). United Kingdom.

    7. Drew Y, Mulligan EA, Vong WT, Thomas HD, Kahn S, Kyle S, Mukhopadhyay A, Los G, Hostomsky Z, Plummer ER, Edmondson RJ, Curtin NJ (2010). Therapeutic potential of poly (ADP-ribose) polymerase Inhibitor AG014699 in human cancers with mutated or methylated BRCA1 or BRCA2. Journal of the National Cancer Institute, Vol 103 (4). United Kingdom

    8. Martin L, Marples B, Coffey M, Lawler M, Hollywood D, Marignol L (2009). Recognition of 06MeG lesions by MGMT and mismatch repair proficiency may be a prerequisite for low-dose radiation hypersensitivity. Radiation Research, Vol 172 (4). Ireland

    9. Welke K, Schneider JM (2009). Inbreeding avoidance through cryptic female choice in the cannibalistic orb-web spider Argiope lobata. Behavioral Ecology, Vol 20 (5). Germany

    10. Schneider JM, Lesmono K (2009). Courtship raises male fertilization success through post-mating sexual selection in a spider. Proceedings in Biological Sciences. Germany

    11. Nessler SH, Uhl G, Schneider JM (2009). Sexual cannibalism facilitates genital damage in Argiope lobata (Araneae: Araneidae). Behavioral Ecoloogy and Sociobiology, Vol 63 (3). Germany

    12. Marignol L, Foley R, Southgate TD, Coffey M, Hollywood D, Lawler M (2009). Hypoxia response element-driven cytosine deaminase/5-fluorocytosine gene therapy system: a highly effective approach to overcome the dynamics of tumour hypoxia and enhance the radiosensitivity of prostate cancer cells in vitro. The Journal of Gene Medicine, Vol 11 (2). Ireland.

    13. Wanner G, Mayer C, Kehlbach R, Rodemann HP, Dittmann K (2008). Activation of protein kinase Cepsilon stimulates DNA-repair via epidermal growth factor receptor nuclear accumulation. Radiotherapy & Oncology, Vol 86 (3). Germany

    14. Dittman K, Mayer C, Kehlbach R, Rodemann HP (2008). Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK. Molecular Cancer, Vol 7 (69). Germany

    15. Prevo R, Deutsch E, Sampson O, Diplexcito J, Cenjel K, Harper J, O'Neill P, McKenna WG, Patel S, Bernhard EJ (2008). Class I PI3 kinase inhibition by the pyridinylfuranopyrimidine Inhibitor PI-103 enhances tumor radiosensitivity. Cancer Research, Vol 68. United Kingdom

    16. Dittmann K, Mayer C, Wanner G, Kehlbach R, Rodemann HP (2007). The radioprotector O-phospho-tyrosine stimulates DNA-repair via epidermal growth factor receptor-and-DNA-dependent kinase phosphorylation. Radiotherapy & Oncology, Vol 84 (3). Germany

    17. Toulany M, Baumann M, Rodemann HP (2007). Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity. Molecular Cancer Research, Vol 5 (8). Germany

    18. Bell E, Premkumar R, Carr J, Lu X, Lovat PE, Kees UR, Lunec J, Tweddle DA (2006). The role of MYCN in the failure of MYCN amplified neuroblastoma cell lines to G1 arrest after DNA damage. Cell Cycle, Vol 5 (22). United Kingdom

    19. Dittmann K, Mayer C, Rodemann HP (2005). Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity. Radiotherapy & Oncology, Vol 76 (2). Germany.

    20. Click for SARRP Publications

Xstrahl

Xstrahl Research Platform Links

  1. Xstrahl RS225 at Nottingham University
  2. UCL London

RS225 RS225 RS225

Applications:

Research applications include:

  • Oncology
  • Radiobiology tumour micro-environment
  • DNA repair
  • Bystander effects
  • Radiosensitivity of normal tissue
  • Preclinical studies
  • Radiosensitizsers

Other applications include:

  • In vivo irradiation

Control System

Operator time is kept to a minimum which enables research application and calibration programs to be easily formulated and programmed into the control systems. Both research and calibration equipment incorporates a touch screen controller.

Links & Downloads


Datasheets
Xstrahl RS225 Data Sheet »
PDF 63 kb

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